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Christina Applegate Says Doctor Ruled Out MS

Published 20 October 2026

Christina Applegate says her doctor has told her she does not have multiple sclerosis, reversing the diagnosis she received in 2021. She shared the news on an October 20 episode of her MeSsy podcast, saying the change has not eased the serious symptoms that have affected her health and mobility. Applegate said she was not relieved because she still does not know what is causing her symptoms. She said she continues to have difficulty walking and needs a wheelchair to get from her car to doctors’ offices. Her condition, she said, has not improved and has worsened in some ways. The actor said her doctors will investigate what has been happening since 2021. The reports provide no alternative diagnosis, and the clinical basis for her doctor’s conclusion has not been publicly detailed. Applegate’s account of the diagnosis change and its effects comes from her podcast; no medical records or direct statement from her treating doctor were provided. Applegate publicly disclosed her MS diagnosis in 2021 and said it had given her an explanation for her symptoms. On the podcast, she described undergoing years of infusion treatment. She said her doctor later stopped the infusions and...

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