Old Dominion vs. South Florida in Cure Bowl

The Old Dominion Monarchs and South Florida Bulls, both finishing the regular season with 9-3 records, meet Wednesday in the StaffDNA Cure Bowl at Camping World Stadium in Orlando, Florida, with kickoff set for 5 p.m. ET on ESPN.

The matchup pits two Conference USA teams against each other in the 11th edition of the bowl game, which supports breast cancer research through its partnership with the Breast Cancer Research Foundation. Old Dominion enters on a five-game winning streak, capped by a 27-10 victory over Georgia State in its finale. The Monarchs allowed an average of 19.5 points per game during the regular season, relying on a stout defense that limited opponents in the red zone. South Florida also won its last two games, including a 52-3 rout of Rice, following an earlier 18-16 upset of then-No. 13 Florida. The Bulls surrendered 23 points per game on average, showing resilience against big plays.

Both teams face significant challenges at quarterback. Old Dominion's starter, Colton Joseph, entered the transfer portal last week and will not play, leaving sophomore Quinn Henicle to make his first career start. South Florida's Byrum Brown has opted out of the game, with...