Officers shot in rural York County, schools and hospital on lockdown.

Multiple law enforcement officers were shot Wednesday afternoon in a rural area of York County, Pennsylvania, prompting school and hospital lockdowns and a large-scale law enforcement response, officials said. The first 911 call reporting an officer down came in at about 2:10 p.m. in North Codorus Township, roughly 115 miles west of Philadelphia, near the Maryland line, authorities said.

Details about casualties remain fluid. A hospital spokesperson said WellSpan York Hospital was treating two people in serious condition related to the incident and had implemented enhanced security protocols. People familiar with the matter told investigators that as many as five officers were shot and that an alleged suspect was believed to have died from a self-inflicted gunshot wound. Other dispatch recordings and initial reports suggested multiple fatalities, but local officials had not confirmed the total number of dead as of late Wednesday.

Pennsylvania State Police are leading the investigation, authorities said, with a heavy police presence and multiple emergency medical transports, including airlifts, reported from the scene. Dispatch logs included calls of "officer down" and a signal...