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Meredith Resumes Research as Jackson Avery Returns to Grey Sloan

Published 31 October 2025

Greys Anatomy returned Thursday night with Episode 4 of Season 22, titled Goodbye Horses, airing at 10 p.m. Eastern on ABC and available to stream the following day on Hulu. The installment centers on the hospital staff at Grey Sloan Memorial as they confront an unusual trauma case and a complex breast reconstruction that forces longtime lead Meredith Grey into a tense surgical partnership.

The episode features the return of Jesse Williams as Jackson Avery, who arrives at Grey Sloan to assist with a reconstructive procedure. Early conflict arises when Meredith criticizes a recently published Alzheimer’s study by Tom Koracick for excluding female subjects, and Jackson defends his mentor. The disagreement ultimately gives way to cooperation when Jackson needs Meredith’s expertise and the two scrub in together. By the episode’s end, their confrontation softens, and Meredith decides to resume research work, a development that sends her away from the hospital again.

Season 22 opened after the previous season ended with a catastrophic hospital explosion, a plotline that continues to influence character decisions and the hospital’s workload. The new episode highlights both the medical...

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