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Damon Wayans to Guest Star on 'St. Denis Medical' Season 3 Premiere

Published 10 August 2026

Damon Wayans is set to guest star in the Season 3 premiere of NBC's workplace comedy "St. Denis Medical," reuniting with his former "In Living Color" castmate David Alan Grier. The actor will play Dr. Highland, a charming yet pompous new physician who arrives at the hospital to fill in while Grier's character, Ron, recovers from heart surgery. The episode is scheduled to air on Monday, November 2, 2026.

According to NBC, Dr. Highland's arrival creates a shift in the hospital's dynamics. While the staff and patients quickly warm to the charismatic newcomer, one key figure remains skeptical. Allison Tolman's character, Alex, is described as unaligned and unimpressed by the new doctor's insights. This setup promises to further explore the personal and professional relationships within the emergency department, which were complicated by the events of the Season 2 finale.

That finale saw Ron undergo serious heart surgery performed by Dr. Brooke Emerson, played by Ariana Madix. In a cliffhanger moment, Ron woke from the procedure and, while still under anesthesia, seemingly confessed to having feelings for executive director Joyce, portrayed by Wendi McLendon-Covey. Series co-creator...

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