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Christina Applegate Memoir Details MS Battle and Pitt Romance

Published 4 March 2026

Christina Applegate, the actress known for her roles in "Married... with Children" and "Dead to Me," released her memoir "You With the Sad Eyes" this week, offering an intimate look at her battle with multiple sclerosis and a long-buried story from her early Hollywood days involving Brad Pitt.

Diagnosed with MS in 2021 at age 49, Applegate has been candid about the condition's toll on her life. In the book, she describes spending most days confined to bed due to intense pain from movement, a stark contrast to her once-active career spanning decades in television and film. Despite the challenges, she prioritizes driving her 15-year-old daughter, Sadie Grace LeNoble, to school each morning, calling it her favorite daily ritual. Applegate's symptoms first emerged during the filming of "Dead to Me's" final season, including severe balance issues that forced her to confront the progressive neurological disease. She has since advocated for awareness, noting in a 2021 social media post that she approaches each day by taking "the indicated action" while requesting privacy during her adjustment.

The memoir delves deeper into Applegate's personal history, revealing a brief romance with...

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