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Watson Season 2 premieres Oct 13 as Holmes resurfaces

Published 16 October 2025

CBS's medical drama Watson returns for its second season on Monday, Oct. 13 at 10 p.m. Eastern, bringing back Dr. John Watson and, unexpectedly, his long presumed dead partner Sherlock Holmes. The season premiere reestablishes Watson as head of a clinic treating rare disorders and ends with Holmes resurfacing in a scene that sets the season's central mystery in motion.

The premiere opens months after Watson's confrontation with James Moriarty and centers on a high‑stakes medical case involving Elizabeth Morstan, the mother of Watson's former partner Mary Morstan. Elizabeth is admitted with rapidly progressing cognitive decline and is later found to have liver failure linked to untreated diabetes. When Mary cannot donate, a long‑lost son, Miles, steps forward to give part of his liver, resolving the immediate medical crisis. The episode concludes, however, with Sherlock Holmes appearing outside the hospital, despite having been declared dead earlier in the story, an ambiguous return that the episode does not directly explain.

The series stars Morris Chestnut as Dr. John Watson and Robert Carlyle as Sherlock Holmes. The ensemble includes Rochelle Aytes as Dr. Mary Morstan, Eve...

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