The Boys S5E5 Reunites Supernatural Alumni Over V1

Prime Video's The Boys reaches a milestone in its final season with Episode 5, "One Shots," set to stream on April 29, 2026, at 12 a.m. PT. The installment features a highly anticipated onscreen reunion of Supernatural alumni Jensen Ackles, Jared Padalecki, and Misha Collins, alongside Antony Starr's Homelander, as the characters clash in a violent pursuit of the original Compound V formula, known as V1.

Ackles reprises his role as Soldier Boy, the powerful supe from Season 3 who shares a fraught paternal history with Homelander. Padalecki debuts as Mister Marathon, The Seven's original speedster who was replaced by A-Train after slowing with age. A fixture in the show's lore since Season 1, the character brings ties to Vought's early days at Seven Tower. Collins portrays Malchemical, a prenatal supe from the series' comic book roots by Garth Ennis. With powers of molecular manipulation, Malchemical can shapeshift into any chemical compound, from metals to gases, and mimic others, though his history includes expulsion from superhero team Team Titanic for impersonating its leader.

A teaser trailer depicts Homelander and Soldier Boy confronting Mister Marathon and Malchemical. "We...