Seahawks to Start Lock Against Cardinals in Week 2 Clash

The Seattle Seahawks will start quarterback Drew Lock in their Week 2 game against the Arizona Cardinals on Sunday, September 20, 2026, due to starter Sam Darnold's glute injury. The matchup is set for 4:25 p.m. ET at State Farm Stadium in Glendale, Arizona, and will air on FOX. Both teams are coming off victories in Week 1. The Seahawks beat the New England Patriots 13-10, while the Cardinals upset the Los Angeles Chargers 26-14 as 9.5-point underdogs. The Seahawks are favored by 3.5 points, with a moneyline of -205 for Seattle and +170 for Arizona, and an over/under of 40.5 points. Lock entered the Patriots game after Darnold's injury on the opening drive and completed 16 of 22 passes for 187 yards and a touchdown. The Seahawks' defense intercepted Drake Maye three times, holding New England to 10 points. Seattle is on a franchise-record 11-game winning streak, including last season's playoff run to the Super Bowl title. The Cardinals' defense showed significant improvement in Week 1, limiting the Chargers to 14 points, 209 passing yards, and 3.9 yards per carry.