No. 9 Ole Miss vs. No. 24 Louisville headlines ACC Week 1

Week 1 of the 2026 college football season is set to deliver a full slate of games featuring the majority of the AP Top 25, with several marquee matchups highlighting the opening weekend. The action begins Thursday, September 3, and extends through Monday, September 7, with a single top-25 clash headlining the schedule. The most anticipated game is a neutral-site showdown between No. 9 Ole Miss and No. 24 Louisville on Sunday, September 6, at Nissan Stadium in Nashville, Tennessee. The contest marks the first game for Ole Miss under new head coach Pete Golding, who takes over after Lane Kiffin's departure. The Rebels, who played in last year's College Football Playoff, are led by quarterback Trinidad Chambliss. Louisville, picked to finish third in the ACC, counters with Ohio State transfer Lincoln Kienholz at quarterback and features running back Isaac Brown, the ACC's 2024 rookie of the year. The game offers an early opportunity for both teams to bolster their College Football Playoff credentials. Another key matchup features No. 11 LSU hosting Clemson on Saturday, September 5, in a primetime game at Tiger Stadium.