Nick Bosa Expected to Miss Weeks With Calf Injury

San Francisco 49ers defensive end Nick Bosa is expected to miss a few weeks after injuring his calf during Thursday’s practice, according to reports attributed to ESPN’s Adam Schefter and NFL Network’s Ian Rapoport. The team is evaluating whether to place him on injured reserve, a decision that would require him to miss at least four games. Bosa will miss San Francisco’s Week 3 game against the Arizona Cardinals, according to the reports. The 49ers are 2-0 after opening the season with wins over the Los Angeles Rams and Miami Dolphins, and his absence leaves the team without a key pass rusher for at least the next game. No exact return date has been established. The 49ers have not announced whether Bosa will go on injured reserve. If they make that move, he would be required to sit out at least four games, potentially extending his absence beyond the reported estimate of a few weeks. If he is not placed on injured reserve, the available reporting still does not specify how many games he will miss or when he could return. Bosa played in San Francisco’s first two games after missing most of the 2025 season with a torn ACL.