Lions Visit Bills for First Game at New Highmark Stadium

The Detroit Lions face the Buffalo Bills in a Thursday Night Football matchup on September 17, 2026, at Highmark Stadium in Orchard Park, New York. The game, scheduled for 8:15 p.m. ET, marks the first regular-season NFL contest at Buffalo's new stadium. Both teams enter with 1-0 records after winning their season openers. The Bills are favored by 4.5 to 5.5 points, with a moneyline of -238 for Buffalo. The projected total points for the game is between 53.5 and 55.5, making it the highest-scoring expectation on the Week 2 schedule. The high over/under line reflects the offensive firepower on both sides. Buffalo opened its season with a 36-31 victory over the Houston Texans. Quarterback Josh Allen threw for 334 yards and two touchdowns, adding two rushing scores. Running back James Cook contributed 115 rushing yards and a touchdown. The Bills' defense, however, allowed 381 yards of offense. Detroit defeated the New Orleans Saints 31-30 in overtime. Quarterback Jared Goff threw for 206 yards and two touchdowns, while running back Jahmyr Gibbs rushed for 156 yards and two scores. Wide receiver Amon-Ra St. Brown caught two touchdown passes.