Large review links prenatal acetaminophen to autism and ADHD risk

A new, large-scale review of the available evidence on acetaminophen use during pregnancy finds that prenatal exposure may be associated with higher risks of autism spectrum disorders and attention-deficit/hyperactivity disorder in children. Drawing on an analysis of 46 studies involving more than 100,000 participants, the researchers say the strongest links emerge in higher-quality investigations, though they stress that the work shows association rather than direct causation. Given the drug’s widespread use among expectant mothers, the findings raise questions about current clinical practices and underscore the need for cautious management of pain and fever during pregnancy.

The study applies a rigorous systematic-review approach to evaluate how well the literature supports any link between prenatal acetaminophen exposure and neurodevelopmental outcomes. The researchers report that about 27 studies found significant associations with autism or ADHD, nine found no link, and four suggested a potential protective effect. They emphasize that while the data do not prove that acetaminophen causes these disorders, the consistency of associations in higher-quality studies strengthens...