Greys Anatomy Season 22 Premieres After Hospital Explosion

Greys Anatomy returns for its 22nd season Thursday, October 9, 2025, with a two-hour network premiere on ABC at 10 p.m. Eastern, 9 p.m. Central. The season opener, titled Only the Strong Survive, resumes immediately after the season 21 cliffhanger in which an explosion at Grey Sloan Memorial Hospital leaves staff and patients in peril. The season will run for 18 episodes airing weekly on Thursday nights, with episodes available to stream on Hulu the following day and on Disney platforms internationally.

The premiere episode centers on hospital staff racing to stabilize victims and protect themselves amid the devastation, with surgeons facing urgent surgical choices and rising emotional strain. Several characters’ fates remain uncertain heading into the new season, including Atticus Link, Miranda Bailey and Ben Warren, whose status was left in question after the blast. Meredith Grey returns in a recurring role and as the series narrator.

A broad ensemble of longrunning cast members is set to return, including Ellen Pompeo as Meredith Grey, Chandra Wilson as Miranda Bailey, James Pickens Jr. as Richard Webber, Kevin McKidd as Owen Hunt, Kim Raver as Teddy Altman, Camilla...