Cardinals Lose 41-22 to 49ers on Record Penalties

GLENDALE, Ariz. The Arizona Cardinals suffered a 41-22 defeat to the San Francisco 49ers on Sunday in Week 11 of the NFL season, a loss marked by franchise-record penalties and a historic performance from quarterback Jacoby Brissett that failed to overcome the team's miscues.

Brissett, starting in place of the injured Kyler Murray, completed 47 of 57 passes for 452 yards and two touchdowns, setting a new NFL record for completions in a regular-season game. The mark surpassed the previous record of 45, shared by Detroit Lions quarterback Jared Goff in 2019 and former New England Patriots quarterback Drew Bledsoe in 1994. Brissett's efficiency stood at 82.5 percent, with career highs in both completions and yards, but he also threw two interceptions. Wide receiver Michael Wilson hauled in 185 yards, while tight end Trey McBride added 115, accounting for 300 of Brissett's yards combined. Despite the Cardinals amassing 488 total offensive yards, more than 200 ahead of San Francisco, the game slipped away early due to self-inflicted errors.

The Cardinals drew a franchise-record 17 penalties for 130 yards, with 11 in the first half alone totaling 85 yards, the most in any NFL half...