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Cardinals' Conner carted off with ankle injury, ruled out vs 49ers

Published 22 September 2025

Arizona Cardinals running back James Conner was carted off Levi's Stadium early in the third quarter of Sunday's game against the San Francisco 49ers after sustaining what the team called an ankle injury, leaving the Cardinals without their starter for the remainder of the contest. Conner was injured on a second-and-1 rushing attempt and was immediately tended to on the field before being placed on a cart and taken to the locker room. The team later ruled him out for the game.

The play unfolded as quarterback Kyler Murray handed the ball to Conner, who was met in the backfield and wrapped up by 49ers defenders. Television replays showed Conner's right ankle bending awkwardly as he went down; he reached for the lower part of that leg and remained on the turf for several minutes while medical staff and players from both teams gathered around him. Cardinals sideline personnel, teammates and some 49ers players accompanied Conner as he was carted off, and several social media posts showed teammates and opponents offering prayers and support.

Conner finished the afternoon with nine carries for 22 yards and three receptions for 15 yards. He had entered the game with 73 rushing yards...

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