49ers Place Aiyuk on Reserve/Left Squad List

The San Francisco 49ers placed wide receiver Brandon Aiyuk on the reserve/left squad list on Saturday, effectively ending his participation in the 2025 season and paving the way for his departure from the team in the offseason.

Aiyuk, 27, has not appeared in a game this season after suffering a severe knee injury in October 2024 during a 28-18 loss to the Kansas City Chiefs. The injury, which included tears to his ACL, MCL and meniscus, sidelined him for the remainder of that year. He began the 2025 training camp on the physically unable to perform list in July and remained there through December, with reports indicating slow progress in his rehabilitation.

The decision to place Aiyuk on the reserve/left squad list follows months of tension between the player and the organization. In November, the 49ers voided the guaranteed portion of his contract for the 2026 season, citing his failure to attend meetings and participate in team activities. According to league sources, Aiyuk's absences were deemed a breach of contractual obligations. He chose not to file a grievance with the NFL Players Association, signaling his acceptance of the move and desire to leave the team.