49ers Beat Cardinals 41-22 on Purdy's Return

The San Francisco 49ers defeated the Arizona Cardinals 41-22 on November 16 at State Farm Stadium in Glendale, Arizona, marking a dominant performance in Week 11 of the NFL season and the return of quarterback Brock Purdy from a turf toe injury that sidelined him for most of the year.

Purdy, who had missed seven games after injuring his toe in the season opener and reinjuring it in Week 4, completed 19 of 26 passes for 200 yards and three touchdowns in his first start since late September. His performance helped the 49ers snap a pattern of close victories amid widespread injuries, delivering their most points since a 42-17 win over the Seattle Seahawks in October 2023. The game began explosively when wide receiver Skyy Moore returned the opening kickoff 99 yards to the Cardinals' 1-yard line, setting up a 1-yard touchdown run by Christian McCaffrey just 16 seconds into the contest. That play ignited an offense that produced four plays of 20 yards or more, including McCaffrey's first 20-plus yard run of the season in the fourth quarter.

The 49ers' defense, hampered by injuries including the season-ending loss of edge rusher Nick Bosa in Week 3, generated three takeaways for the...